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Effectiveness of the adapted bivalent mRNA COVID-19 vaccines against hospitalisation in individuals aged ≥ 60 years during the Omicron XBB lineage-predominant period: VEBIS SARI VE network, Europe, February to August, 2023.


ABSTRACT: We conducted a multicentre hospital-based test-negative case-control study to measure the effectiveness of adapted bivalent COVID-19 mRNA vaccines against PCR-confirmed SARS-CoV-2 infection during the Omicron XBB lineage-predominant period in patients aged ≥ 60 years with severe acute respiratory infection from five countries in Europe. Bivalent vaccines provided short-term additional protection compared with those vaccinated > 6 months before the campaign: from 80% (95% CI: 50 to 94) for 14-89 days post-vaccination, 15% (95% CI: -12 to 35) at 90-179 days, and lower to no effect thereafter.

SUBMITTER: Antunes L 

PROVIDER: S-EPMC10797659 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Effectiveness of the adapted bivalent mRNA COVID-19 vaccines against hospitalisation in individuals aged ≥ 60 years during the Omicron XBB lineage-predominant period: VEBIS SARI VE network, Europe, February to August, 2023.

Antunes Liliana L   Mazagatos Clara C   Martínez-Baz Iván I   Gomez Verónica V   Borg Maria-Louise ML   Petrović Goranka G   Duffy Róisín R   Dufrasne François E FE   Dürrwald Ralf R   Lazar Mihaela M   Jancoriene Ligita L   Oroszi Beatrix B   Husa Petr P   Howard Jennifer J   Melo Aryse A   Pozo Francisco F   Pérez-Gimeno Gloria G   Castilla Jesús J   Machado Ausenda A   Džiugytė Aušra A   Karabuva Svjetlana S   Fitzgerald Margaret M   Fierens Sébastien S   Tolksdorf Kristin K   Popovici Silvia-Odette SO   Mickienė Auksė A   Túri Gergő G   Součková Lenka L   Nicolay Nathalie N   Rose Angela Mc AM  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20240101 3


We conducted a multicentre hospital-based test-negative case-control study to measure the effectiveness of adapted bivalent COVID-19 mRNA vaccines against PCR-confirmed SARS-CoV-2 infection during the Omicron XBB lineage-predominant period in patients aged ≥ 60 years with severe acute respiratory infection from five countries in Europe. Bivalent vaccines provided short-term additional protection compared with those vaccinated > 6 months before the campaign: from 80% (95% CI: 50 to 94) for 14-89  ...[more]

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