Faecalibacterium prausnitzii as a potential Antiatherosclerotic microbe.

ABSTRACT:

Background

The gut microbiota plays a crucial role in coronary artery disease (CAD) development, but limited attention has been given to the role of the microbiota in preventing this disease. This study aimed to identify key biomarkers using metagenomics and untargeted metabolomics and verify their associations with atherosclerosis.

Methods

A total of 371 participants, including individuals with various CAD types and CAD-free controls, were enrolled. Subsequently, significant markers were identified in the stool samples through gut metagenomic sequencing and untargeted metabolomics. In vivo and in vitro experiments were performed to investigate the mechanisms underlying the association between these markers and atherosclerosis.

Results

Faecal omics sequencing revealed

SUBMITTER: Yang HT 

PROVIDER: S-EPMC10797727 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature