Partial oral versus full intravenous antibiotic treatment of endocarditis in people who inject drugs: A systematic review.

ABSTRACT:

Background

Prolonged intravenous (IV) antibiotic therapy may not be optimal for people who inject drugs (PWID) with infective endocarditis (IE) due to unique social and medical needs. The role of partial IV antibiotic therapy with continued oral (PO) antibiotic therapy is unclear.

Methods

A systematic review was performed using EMBASE and MEDLINE databases. Included studies compared PO to IV antibiotic treatment for IE in PWID.

Results

Four studies met eligibility. Observational studies included full IV treatment groups and partial IV, partial PO treatment groups for severe injection-related infections. PWID with IE comprised 41.0%-64.7% of the study populations but outcomes specific to IE were not separately reported. All-cause 90-day readmission rates were comparabl

SUBMITTER: Brown A 

PROVIDER: S-EPMC10797769 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature