Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients.

ABSTRACT:

Background

Colibactin, a genotoxin produced by polyketide synthase harboring (pks⁺) bacteria, induces double-strand breaks and chromosome aberrations. Consequently, enrichment of pks⁺Escherichia coli in colorectal cancer and polyposis suggests a possible carcinogenic effect in the large intestine. Additionally, specific colibactin-associated mutational signatures; SBS88 and ID18 in the Catalogue of Somatic Mutations in Cancer database, are detected in colorectal carcinomas. Previous research showed that a recurrent APC splice variant perfectly fits SBS88.

Methods

In this study, we explore the presence of colibactin-associated signatures and fecal pks in an unexplained polyposis cohort. Somatic targeted Next-Generation Sequencing (NGS) was performed for

SUBMITTER: Terlouw D 

PROVIDER: S-EPMC10797792 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature