Association between cerebrospinal fluid pressure and cognition in patients with Alzheimer's disease and Lewy body dementia.

ABSTRACT:

Background

The relationship between cerebrospinal fluid pressure (CSFP) and cognition has received little research attention. The purpose of this study was to explore the relationship between CSFP and cognition in patients with Alzheimer's disease (AD) and patients with Lewy body dementia (LBD).

Method

We included 178 participants, including 137 patients with AD and 41 patients with LBD (including dementia with Lewy bodies (DLBs) and Parkinson's disease dementia (PDD)). CSFP was measured by lumbar puncture, and a patient-reported history and laboratory test data were collected. Logistic and linear regression analyses were used to evaluate the associations between CSFP and cognition, the cerebrospinal fluid (CSF) / serum albumin ratio (Qalb), and CSF biomarkers of AD.

Resu

SUBMITTER: Yang X 

PROVIDER: S-EPMC10797877 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature