Comprehensive full genome analysis of norovirus strains from eastern India, 2017-2021.

ABSTRACT:

Background

Worldwide, noroviruses are the leading cause of acute gastroenteritis (AGE) in people of all age groups. In India, norovirus rates between 1.4 to 44.4% have been reported. Only a very few complete norovirus genome sequences from India have been reported.

Objective

To perform full genome sequencing of noroviruses circulating in India during 2017-2021, identify circulating genotypes, assess evolution including detection of recombination events.

Methodology

Forty-five archived norovirus-positive samples collected between October 2017 to July 2021 from patients with AGE from two hospitals in Kolkata, India were processed for full genome sequencing. Phylogenetic analysis, recombination breakpoint analysis and comprehensive mutation analysis were also performed.<

SUBMITTER: Lo M 

PROVIDER: S-EPMC10797879 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature