Sex-specific differences in intestinal microbiota associated with cardiovascular diseases.

ABSTRACT:

Background

Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence in men than women. This study aims to evaluate the variations in the intestinal microbiota between men and women afflicted with CHD and delineate these against a non-CVD control group for each sex.

Methods

Our research was conducted in the framework of the CORDIOPREV study, a clinical trial which involved 837 men and 165 women with CHD. We contrasted our findings with a reference group of 375 individuals (270 men, 105 women) without CVD. The intestinal microbiota was examined through 16S metagenomics on the Illumina MiSeq platform and the data processed with Quiime2 software.

Results

Our results showed a sex-specific variation (beta diversity) in the intestina

SUBMITTER: Garcia-Fernandez H 

PROVIDER: S-EPMC10797902 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature