What is the actual relationship between neutrophil extracellular traps and COVID-19 severity? A longitudinal study.

ABSTRACT:

Background

Neutrophil extracellular traps (NETs) have repeatedly been related to COVID-19 severity and mortality. However, there is no consensus on their quantification, and there are scarce data on their evolution during the disease. We studied circulating NET markers in patients with COVID-19 throughout their hospitalization.

Methods

We prospectively included 93 patients (201 blood samples), evaluating the disease severity in 3 evolutionary phases (viral, early, and late inflammation). Of these, 72 had 180 samples in various phases. We also evaluated 55 controls with similar age, sex and comorbidities. We measured 4 NET markers in serum: cfDNA, CitH3, and MPO-DNA and NE-DNA complexes; as well as neutrophil-related cytokines IL-8 and G-CSF.

Results

The COVID-19 group

SUBMITTER: de Diego C 

PROVIDER: S-EPMC10797938 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature