Association between vaccination rates and COVID-19 health outcomes in the United States: a population-level statistical analysis.

ABSTRACT:

Background

Population-level vaccine efficacy is a critical component of understanding COVID-19 risk, informing public health policy, and mitigating disease impacts. Unlike individual-level clinical trials, population-level analysis characterizes how well vaccines worked in the face of real-world challenges like emerging variants, differing mobility patterns, and policy changes.

Methods

In this study, we analyze the association between time-dependent vaccination rates and COVID-19 health outcomes for 48 U.S. states. We primarily focus on case-hospitalization risk (CHR) as the outcome of interest, using it as a population-level proxy for disease burden on healthcare systems. Performing the analysis using Generalized Additive Models (GAMs) allowed us to incorporate real-world n

SUBMITTER: Du H 

PROVIDER: S-EPMC10797940 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature