High genetic diversity and different type VI secretion systems in Enterobacter species revealed by comparative genomics analysis.

ABSTRACT: The human-pathogenic Enterobacter species are widely distributed in diverse environmental conditions, however, the understanding of the virulence factors and genetic variations within the genus is very limited. In this study, we performed comparative genomics analysis of 49 strains originated from diverse niches and belonged to eight Enterobacter species, in order to further understand the mechanism of adaption to the environment in Enterobacter. The results showed that they had an open pan-genome and high genomic diversity which allowed adaptation to distinctive ecological niches. We found the number of secretion systems was the highest among various virulence factors in these Enterobacter strains. Three types of T6SS gene clusters including T6SS-A, T6SS-B and T6SS-C were detected in most

SUBMITTER: Peng M 

PROVIDER: S-EPMC10797944 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature