Genomic insights into Plasmodium vivax population structure and diversity in central Africa.

ABSTRACT:

Background

Though Plasmodium vivax is the second most common malaria species to infect humans, it has not traditionally been considered a major human health concern in central Africa given the high prevalence of the human Duffy-negative phenotype that is believed to prevent infection. Increasing reports of asymptomatic and symptomatic infections in Duffy-negative individuals throughout Africa raise the possibility that P. vivax is evolving to evade host resistance, but there are few parasite samples with genomic data available from this part of the world.

Methods

Whole genome sequencing of one new P. vivax isolate from the Democratic Republic of the Congo (DRC) was performed and used in population genomics analyses to assess how this central African isolate fits into the glo

SUBMITTER: Gartner V 

PROVIDER: S-EPMC10797969 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature