Sulfamate-Tethered Aza-Wacker Strategy for a Kasugamine Synthon.

ABSTRACT: We present our preparation of a kasugamine synthon, which proceeds in 14 steps from a literature epoxide. We expect that this kasugamine derivative can be used for the total syntheses of kasugamycin, minosaminomycin, and analogue antibiotics. A key step in the synthesis is our laboratory's sulfamate-tethered aza-Wacker cyclization.

SUBMITTER: Mandal GH 

PROVIDER: S-EPMC10798055 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature