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Sulfamate-Tethered Aza-Wacker Strategy for a Kasugamine Synthon.

ABSTRACT: We present our preparation of a kasugamine synthon, which proceeds in 14 steps from a literature epoxide. We expect that this kasugamine derivative can be used for the total syntheses of kasugamycin, minosaminomycin, and analogue antibiotics. A key step in the synthesis is our laboratory's sulfamate-tethered aza-Wacker cyclization.

SUBMITTER: Mandal GH

PROVIDER: S-EPMC10798055 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Sulfamate-Tethered Aza-Wacker Strategy for a Kasugamine Synthon.

Mandal Gour Hari GH Sathyamoorthi Shyam S

The Journal of organic chemistry 20231208 1

We present our preparation of a kasugamine synthon, which proceeds in 14 steps from a literature epoxide. We expect that this kasugamine derivative can be used for the total syntheses of kasugamycin, minosaminomycin, and analogue antibiotics. A key step in the synthesis is our laboratory's sulfamate-tethered aza-Wacker cyclization. ...[more]

PMID: 38062940

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