Comparative analysis of the Saccharomyces cerevisiae and Caenorhabditis elegans protein interaction networks.

ABSTRACT:

Background

Protein interaction networks aim to summarize the complex interplay of proteins in an organism. Early studies suggested that the position of a protein in the network determines its evolutionary rate but there has been considerable disagreement as to what extent other factors, such as protein abundance, modify this reported dependence.

Results

We compare the genomes of Saccharomyces cerevisiae and Caenorhabditis elegans with those of closely related species to elucidate the recent evolutionary history of their respective protein interaction networks. Interaction and expression data are studied in the light of a detailed phylogenetic analysis. The underlying network structure is incorporated explicitly into the statistical analysis. The increased phylogenetic resolu

SUBMITTER: Agrafioti I 

PROVIDER: S-EPMC1079807 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature