The impact of environmental contaminants on extracellular vesicles and their key molecular regulators: A literature and database-driven review.

ABSTRACT: Exposure to environmental chemicals is now well recognized as a significant factor contributing to the global burden of disease; however, there remain critical gaps in understanding the types of biological mechanisms that link environmental chemicals to adverse health outcomes. One type of mechanism that remains understudied involves extracellular vesicles (EVs), representing small cell-derived particles capable of carrying molecular signals such as RNAs, miRNAs, proteins, lipids, and chemicals through biological fluids and imparting beneficial, neutral, or negative effects on target cells. In fact, evidence is just now starting to grow that supports the role of EVs in various disease etiologies. This review aims to (1) Provide a landscape of the current understanding of the functional rel

SUBMITTER: Carberry CK 

PROVIDER: S-EPMC10798145 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature