Reversal of cholestatic liver disease by the inhibition of sphingosine 1-phosphate receptor 2 signaling.

ABSTRACT:

Aims

The objective of this study is to examine the impact of inhibiting Sphingosine 1-phosphate receptor 2 (S1PR2) on liver inflammation, fibrogenesis, and changes of gut microbiome in the context of cholestasis-induced conditions.

Methods

The cholestatic liver injury model was developed by common bile duct ligation (CBDL). Sprague-Dawley rats were randomly allocated to three groups, sham operation, CBDL group and JTE-013 treated CBDL group. Biochemical and histological assessments were conducted to investigate the influence of S1PR2 on the modulation of fibrogenic factors and inflammatory infiltration. We conducted an analysis of the fecal microbiome by using 16S rRNA sequencing. Serum bile acid composition was evaluated through the utilization of liquid chromatography-mass

SUBMITTER: Cao H 

PROVIDER: S-EPMC10798156 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature