Complement dysregulation and Alzheimer's disease in Down syndrome.

ABSTRACT:

Introduction

Down syndrome (DS) is associated with immune dysregulation and a high risk of early onset Alzheimer's disease (AD). Complement is a key part of innate immunity and driver of pathological inflammation, including neuroinflammation in AD. Complement dysregulation has been reported in DS; however, the pattern of dysregulation and its relationship to AD risk is unclear.

Methods

Plasma levels of 14 complement biomarkers were measured in 71 adults with DS and 46 controls to identify DS-associated dysregulation; impact of apolipoprotein E (APOE) ε4 genotype, single nucleotide polymorphisms (SNPs) in CLU and CR1, and dementia on complement biomarkers was assessed.

Results

Plasma levels of complement activation products (TCC, iC3b), proteins (C1q, C3, C9), and regu

SUBMITTER: Veteleanu A 

PROVIDER: S-EPMC10798358 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature