Causal relationship between COVID-19 and chronic pain: A mendelian randomization study.

ABSTRACT:

Objective

COVID-19 is a highly transmissible disease that can result in long-term symptoms, including chronic pain. However, the mechanisms behind the persistence of long-COVID pain are not yet fully elucidated, highlighting the need for further research to establish causality. Mendelian randomization (MR), a statistical technique for determining a causal relationship between exposure and outcome, has been employed in this study to investigate the association between COVID-19 and chronic pain.

Material and methods

The IVW, MR Egger, and weighted median methods were employed. Heterogeneity was evaluated using Cochran's Q statistic. MR Egger intercept and MR-PRESSO tests were performed to detect pleiotropy. The Bonferroni method was employed for the correction of multiple test

SUBMITTER: Fan Y 

PROVIDER: S-EPMC10798446 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature