Myeloid cells in the era of cancer immunotherapy: Top 3 unanswered questions.

ABSTRACT: Myeloid cells are increasingly being recognized as central players orchestrating or suppressing antitumor immune responses. With the advent of high-resolution analytical methods such as single-cell technologies, we now appreciate the heterogeneity and complexity of the myeloid compartment in the context of cancer. Because of their highly plastic nature, targeting myeloid cells has shown promising results either as a monotherapy or in combination with immunotherapy in preclinical models and cancer patients. However, the complexity of myeloid cell cellular crosstalk and molecular networks contributes to our poor understanding of the different myeloid cell subsets in tumorigenesis, which makes targeting myeloid cells challenging. Here, we summarize varied myeloid cell subsets and their contri

SUBMITTER: Chaib M 

PROVIDER: S-EPMC10798582 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature