Resuscitation With Early Adrenaline Infusion for Children With Septic Shock: A Randomized Pilot Trial.

ABSTRACT:

Objectives

In children with septic shock, guidelines recommend resuscitation with 40-60 mL/kg of fluid boluses, yet there is a lack of evidence to support this practice. We aimed to determine the feasibility of a randomized trial comparing early adrenaline infusion with standard fluid resuscitation in children with septic shock.

Design

Open-label parallel randomized controlled, multicenter pilot study. The primary end point was feasibility; the exploratory clinical endpoint was survival free of organ dysfunction by 28 days.

Setting

Four pediatric Emergency Departments in Queensland, Australia.

Patients

Children between 28 days and 18 years old with septic shock.

Interventions

Patients were assigned 1:1 to receive a continuous adrenaline infusion after 20

SUBMITTER: Harley A 

PROVIDER: S-EPMC10798589 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature