Trained immunity in recurrent Staphylococcus aureus infection promotes bacterial persistence.

ABSTRACT: Bacterial persister cells, a sub-population of dormant phenotypic variants highly tolerant to antibiotics, present a significant challenge for infection control. Investigating the mechanisms of antibiotic persistence is crucial for developing effective treatment strategies. Here, we found a significant association between tolerance frequency and previous infection history in bovine mastitis. Previous S. aureus infection led to S. aureus tolerance to killing by rifampicin in subsequent infection in vivo and in vitro. Actually, the activation of trained immunity contributed to rifampicin persistence of S. aureus in secondary infection, where it reduced the effectiveness of antibiotic treatment and increased disease severity. Mechanically, we found that S. aureus persistence was mediated by t

SUBMITTER: Lin XQ 

PROVIDER: S-EPMC10798626 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature