A Bayesian generating function approach to adverse drug reaction screening.

ABSTRACT: Determining causality of an adverse drug reaction (ADR) requires a multifactor assessment. The classic Naranjo algorithm is still the dominant assessment tool used to determine causality. But, in spite of its effectiveness, the Naranjo algorithm is manually intensive and impractical for assessing very many ADRs and drug combinations. Thus, over the years, many "automated" algorithms have been developed in an attempt to determine causality. By-and-large, these algorithms are either regression-based or Bayesian. In general, the automatic algorithms have several major drawbacks that preclude fully automated causality assessment. Therefore, signal detection (or causality screening) plays a role in a "first pass" of large ADR databases to limit the number of ADR/drug combinations a skilled huma

SUBMITTER: Northardt T 

PROVIDER: S-EPMC10798640 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature