Alterations in nasal microbiota of patients with amyotrophic lateral sclerosis.

ABSTRACT:

Background

Links between alterations in gut microbiota composition and amyotrophic lateral sclerosis (ALS) have previously been reported. This study aimed to examine the microbiota in the nasal cavity of ALS.

Methods

Sixty-six ALS patients and 40 healthy caregivers who live in close proximity with patients were enrolled. High throughput metagenomic sequencing of the 16S ribosomal deoxyribonucleic acid (rDNA) gene V3-V4 region of nasal microbiota was used to characterize the alpha and beta diversity and relative abundance of bacterial taxa, predict function, and conduct correlation analysis between specific taxa and clinical features.

Results

The nasal microbiome of ALS patients showed lower alpha diversity than that of corresponding healthy family members. Genera Gaie

SUBMITTER: Liu K 

PROVIDER: S-EPMC10798702 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature