A polymorphism at codon 31 of gene p21 is not associated with primary open angle glaucoma in Caucasians.

ABSTRACT:

Background

Primary open angle glaucoma (POAG) is considered to be a neurodegenerative optic neuropathy, in which cell death occurs by apoptosis. p21, is an important protective component of the apoptotic pathway, regulating cellular arrest in the presence of DNA damage. An unstable or altered p21 protein could modify the cellular response to genomic injury and abolish the effect of p21. A previous study on a Chinese cohort suggested that the p21 codon 31 polymorphism may alter the state of apoptosis in glaucomatous optic neuropathy, failing to protect the ganglion cells. The aim of this study was to test the hypothesis that a p21 codon 31 polymorphism is associated with POAG on a Caucasian cohort.

Methods

140 POAG patients and a control group of 73 healthy individuals were i

SUBMITTER: Ressiniotis T 

PROVIDER: S-EPMC1079871 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature