Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose-Response Meta-Analysis.

ABSTRACT:

Objectives

To perform a systematic review and meta-analysis to assess the efficacy and safety of corticosteroids in patients with sepsis.

Data sources

We searched PubMed, Embase, and the Cochrane Library, up to January 10, 2023.

Study selection

We included randomized controlled trials (RCTs) comparing corticosteroids with placebo or standard care with sepsis.

Data extraction

The critical outcomes of interest included mortality, shock reversal, length of stay in the ICU, and adverse events.

Data analysis

We performed both a pairwise and dose-response meta-analysis to evaluate the effect of different corticosteroid doses on outcomes. We used Grading of Recommendations Assessment, Development and Evaluation to assess certainty in pooled estimates.

Data s

SUBMITTER: Pitre T 

PROVIDER: S-EPMC10798738 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature