Exercise responsive genes measured in peripheral blood of women with chronic fatigue syndrome and matched control subjects.

ABSTRACT:

Background

Chronic fatigue syndrome (CFS) is defined by debilitating fatigue that is exacerbated by physical or mental exertion. To search for markers of CFS-associated post-exertional fatigue, we measured peripheral blood gene expression profiles of women with CFS and matched controls before and after exercise challenge.

Results

Women with CFS and healthy, age-matched, sedentary controls were exercised on a stationary bicycle at 70% of their predicted maximum workload. Blood was obtained before and after the challenge, total RNA was extracted from mononuclear cells, and signal intensity of the labeled cDNA hybridized to a 3800-gene oligonucleotide microarray was measured. We identified differences in gene expression among and between subject groups before and after exercise

SUBMITTER: Whistler T 

PROVIDER: S-EPMC1079885 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature