A comprehensive update of the sequence and structure classification of kinases.

ABSTRACT:

Background

A comprehensive update of the classification of all available kinases was carried out. This survey presents a complete global picture of this large functional class of proteins and confirms the soundness of our initial kinase classification scheme.

Results

The new survey found the total number of kinase sequences in the protein database has increased more than three-fold (from 17,310 to 59,402), and the number of determined kinase structures increased two-fold (from 359 to 702) in the past three years. However, the framework of the original two-tier classification scheme (in families and fold groups) remains sufficient to describe all available kinases. Overall, the kinase sequences were classified into 25 families of homologous proteins, wherein 22 families (appr

SUBMITTER: Cheek S 

PROVIDER: S-EPMC1079889 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature