PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα.

ABSTRACT: The over-activation of ERα signaling is regarded as the major driver for luminal breast cancers, which could be effective controlled via selective estrogen receptor modulators (SERM), such as tamoxifen. The endocrine resistance is still a challenge for breast cancer treatment, while recently studies implicate the post-translational modification on ERα play important roles in endocrine resistance. The stability of ERα protein and ERα transcriptome are subject to a balance between E3 ubiquitin ligases and deubiquitinases. Through deubiquitinases siRNA library screening, we discover PSMD14 as a critical deubiquitinase for ERα signaling and breast cancer progression. PSMD14 could facilitate breast cancer progression through ERα signaling in vitro and in vivo, while pharmaceutical inhibition of

SUBMITTER: Yang P 

PROVIDER: S-EPMC10798890 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature