Mesenchymal stem cell therapy in perinatal arterial ischemic stroke: systematic review of preclinical studies.

ABSTRACT:

Background

Perinatal arterial ischemic stroke (PAIS) is a neurologic disorder leading to long-term complications. Mesenchymal stem cells (MSCs) have emerged as a novel therapeutic agent. This systematic review aims to determine the effects of stem cell-based interventions for the treatment of PAIS in preclinical studies.

Methods

We included all controlled studies on MSCs in neonatal animals with PAIS. Functional outcome was the primary outcome. The literature search was performed in February 2021.

Results

In the 20 included studies, MSCs were most frequently delivered via intracerebral injection (n = 9), 3 days after the induction of PAIS (n = 8), at a dose ranging from 5 × 10⁴ to 5 × 10⁶ cells. The meta-analysis showed an improvement on the cyli

SUBMITTER: Lehnerer V 

PROVIDER: S-EPMC10798891 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature