Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez Tirado C
PROVIDER: S-EPMC10798893 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Rodriguez Tirado Carla C Wang Choushi C Li Xiaoling X Deng Su S Gonzalez Julisa J Johnson Nickolas A NA Xu Yaru Y Metang Lauren A LA Sundar Rajan Medha M Yang Yuqiu Y Yin Yi Y Hofstad Mia M Raj Ganesh V GV Zhang Song S Lemoff Andrew A He Wei W Fan Jie J Wang Yunguan Y Wang Tao T Mu Ping P
Oncogene 20231129 4
Prostate cancer (PCa) is primarily driven by aberrant Androgen Receptor (AR) signaling. Although there has been substantial advancement in antiandrogen therapies, resistance to these treatments remains a significant obstacle, often marked by continuous or enhanced AR signaling in resistant tumors. While the dysregulation of the ubiquitination-based protein degradation process is instrumental in the accumulation of oncogenic proteins, including AR, the molecular mechanism of ubiquitination-driven ...[more]