Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study.

ABSTRACT:

Background

The first-pass meconium has been suggested as a proxy for the fetal gut microbiota because it is formed in utero. This systematic review and cohort study investigated how pre- and perinatal factors influence the composition of the meconium microbiota.

Methods

We performed the systematic review using Covidence by searching PubMed, Scopus, and Web of Science databases with the search terms "meconium microbiome" and "meconium microbiota". In the cohort study, we performed 16 S rRNA gene sequencing on 393 meconium samples and analyzed the sequencing data using QIIME2.

Results

Our systematic review identified 69 studies exploring prenatal factors, immediate perinatal factors, and microbial composition in relation to subsequent health of infants but gave only lim

SUBMITTER: Turunen J 

PROVIDER: S-EPMC10798900 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature