NADase CD38 is a key determinant of ovarian aging.

ABSTRACT: The ovary ages earlier than most other tissues, yet the underlying mechanisms remain elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in young and middle-aged mice revealed that the ovaries showed earlier expression of age-associated genes, identifying increased NADase CD38 expression and decreased NAD⁺ levels in the ovary of middle-aged mice. Bulk and single-cell RNA sequencing revealed that CD38 deletion mitigated ovarian aging, preserving fertility and follicle reserve in aged mice by countering age-related gene expression changes and intercellular communication alterations. Mechanistically, the earlier onset of inflammation induced higher expression levels of CD38 and decreased NAD⁺ levels in the ovary, thereby accelerating o

SUBMITTER: Yang Q 

PROVIDER: S-EPMC10798903 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature