Casodex treatment induces hypoxia-related gene expression in the LNCaP prostate cancer progression model.

ABSTRACT:

Background

The changes in gene expression profile as prostate cancer progresses from an androgen-dependent disease to an androgen-independent disease are still largely unknown.

Methods

We examined the gene expression profile in the LNCaP prostate cancer progression model during chronic treatment with Casodex using cDNA microarrays consisting of 2305 randomly chosen genes.

Results

Our studies revealed a representative collection of genes whose expression was differentially regulated in LNCaP cells upon treatment with Casodex. A set of 15 genes were shown to be highly expressed in Casodex-treated LNCaP cells compared to the reference sample. This set of highly expressed genes represents a signature collection unique to prostate cancer since their expression was signific

SUBMITTER: Rothermund CA 

PROVIDER: S-EPMC1079894 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature