Effects of lockdowns on neurobiological and psychometric parameters in unipolar depression during the COVID-19 pandemic.

ABSTRACT: Defying the COVID-19 pandemic required restriction measures of unprecedented scale, that may induce and exacerbate psychiatric symptoms across the population. We aimed to assess in vivo dynamic effects of mitigation strategies on human brain neurobiology, neuroplastic as well as psychometric parameters. Three structural magnetic resonance imaging measurements, serum brain-derived neurotrophic factor (sBDNF) analyses, and psychometric assessments (Beck Depression Inventory-II and Perceived Stress Questionnaire-20) were performed in healthy individuals and patients with a recurrent major depressive disorder in the period from September 2020 to July 2021. Group differences and changes over time in structural imaging, neuroplastic and psychometric parameters were assessed with linear mixed mod

SUBMITTER: Unterholzner J 

PROVIDER: S-EPMC10798945 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature