PSGL-1 decorated with sialyl Lewis^a/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.

ABSTRACT: Dissemination of multiple myeloma into the bone marrow proceeds through sequential steps mediated by a variety of adhesion molecules and chemokines that eventually results in the extravasation of malignant plasma cells into this protective niche. Selectins are a class of C-type lectins that recognize carbohydrate structures exposed on blood borne cells and participate in the first step of the extravasation cascade, serving as brakes to slow down circulating cells enabling them to establish firm adhesion onto the endothelium. Myeloma cells enriched for the expression of selectin ligands present an aggressive disease in vivo that is refractory to bortezomib treatment and can be reverted by small molecules targeting E-selectin. In this study, we have defined the molecular determinants of the

SUBMITTER: O'Dwyer M 

PROVIDER: S-EPMC10798956 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature