AMPKα2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation.

ABSTRACT: Ketone bodies serve as an energy source, especially in the absence of carbohydrates or in the extended exercise. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a crucial energy sensor that regulates lipid and glucose metabolism. However, whether AMPK regulates ketone metabolism in whole body is unclear even though AMPK regulates ketogenesis in liver. Prolonged resulted in a significant increase in blood and urine levels of ketone bodies in wild-type (WT) mice. Interestingly, fasting AMPKα2^-/- and AMPKα1^-/- mice exhibited significantly higher levels of ketone bodies in both blood and urine compared to fasting WT mice. BHB tolerance assays revealed that both AMPKα2^-/- and AMPKα1^-/- mice exhibited slower ketone consumption compared

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10798978 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature