A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets.

ABSTRACT: Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the mechanisms that may underlie its anti-addictive effects are still not defined. This study aims to identify changes in gene expression induced by a single oral dose of IBO in the cortex of mice by means of a transcriptomic analysis for the first time. Our results showed significant alterations in gene expression in mouse frontal cortex samples 4 h after a single oral dose of IBO. Specifically, genes involved in hormonal pathways and synaptogenesis exhibited upregulation, while genes associated with apoptotic processes and endosomal transports showed downregulation. The findings were further corroborated through quantitative polymerase chain reaction (qPCR) analysis. However, the validation of gene exp

SUBMITTER: Biosca-Brull J 

PROVIDER: S-EPMC10798990 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature