CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in Parkinson's disease.

ABSTRACT: Seed amplification assays have been implemented in Parkinson's disease to reveal disease-specific misfolded alpha-synuclein aggregates in biospecimens. While the assays' qualitative dichotomous seeding response is valuable to stratify and enrich cohorts for alpha-synuclein pathology in general, more quantitative parameters that are associated with clinical dynamics of disease progression and that might potentially serve as exploratory outcome measures in clinical trials targeting alpha-synuclein would add important information. To evaluate whether the seeding kinetic parameters time required to reach the seeding threshold (LAG phase), the peak of fluorescence response (Imax), and the area under the curve (AUC) are associated with clinical trajectories, we analyzed LAG, Imax, and AUC in rel

SUBMITTER: Brockmann K 

PROVIDER: S-EPMC10799016 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature