Old and new strategies in therapy and diagnosis against fungal infections.

ABSTRACT: Fungal infections represent a serious global health threat. The new emerging pathogens and the spread of different forms of resistance are now hardly challenging the tools available in therapy and diagnostics. With the commonly used diagnoses, fungal identification is often slow and inaccurate, and, on the other hand, some drugs currently used as treatments are significantly affected by the decrease in susceptibility. Herein, the antifungal arsenal is critically summarized. Besides describing the old approaches and their mechanisms, advantages, and limitations, the focus is dedicated to innovative strategies which are designed, identified, and developed to take advantage of the discrepancies between fungal and host cells. Relevant pathways and their role in survival and virulence are discu

SUBMITTER: Vanzolini T 

PROVIDER: S-EPMC10799149 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature