FSTL3 is associated with prognosis and immune cell infiltration in lung adenocarcinoma.

ABSTRACT:

Purpose

FSTL3 expression is altered in various types of cancer. However, the role and mechanism of action of FSTL3 in lung adenocarcinoma development and tumor immunity are unknown. We investigated the association between FSTL3 expression and clinical characteristics and immune cell infiltration in lung adenocarcinoma samples from The Cancer Genome Atlas (TCGA) and a separate validation set from our hospital.

Methods

Data on immune system infiltration, gene expression, and relevant clinical information were obtained by analyzing lung adenocarcinoma sample data from TCGA database. Using online tools like GEPIA, the correlations between FSTL3 expression and prognosis, clinical stage, survival status, and tumor-infiltrating immune cells were examined. In a validation dataset, i

SUBMITTER: Meng X 

PROVIDER: S-EPMC10799152 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature