Pulsatile microvascular cerebral blood flow waveforms change with intracranial compliance and age.

ABSTRACT:

Significance

Diffuse correlation spectroscopy (DCS) is an optical method to measure relative changes in cerebral blood flow (rCBF) in the microvasculature. Each heartbeat generates a pulsatile signal with distinct morphological features that we hypothesized to be related to intracranial compliance (ICC).

Aim

We aim to study how three features of the pulsatile rCBF waveforms: the augmentation index (AIx), the pulsatility index, and the area under the curve, change with respect to ICC. We describe ICC as a combination of vascular compliance and extravascular compliance.

Approach

Since patients with Chiari malformations (CM) (n=30) have been shown to have altered extravascular compliance, we compare the morphology of rCBF waveforms in CM patients with age-matched healthy

SUBMITTER: Kedia N 

PROVIDER: S-EPMC10799239 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature