Timing of Maternal COVID-19 Vaccine and Antibody Concentrations in Infants Born Preterm.

ABSTRACT:

Importance

COVID-19 vaccine-derived antibodies in pregnant people may protect infants from severe infection in the first 6 months of life via transplacental antibody transfer. Few data exist on maternally derived SARS-CoV-2 antibodies in preterm compared with full-term infants in association with vaccination timing.

Objective

To compare SARS-CoV-2 anti-Spike (anti-S) antibody levels in preterm and full-term infants in the context of vaccine dose timing before delivery.

Design, setting, and participants

This prospective cohort study enrolled pregnant individuals and collected paired maternal and cord blood samples at delivery at the University of Washington between February 1, 2021, and January 31, 2023. Participants who had received at least 2 doses of a messenger RNA

SUBMITTER: Kachikis A 

PROVIDER: S-EPMC10799259 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature