Dose-Response Associations of Lipid Traits With Coronary Artery Disease and Mortality.

ABSTRACT:

Importance

Apolipoprotein B (apoB), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) are associated with coronary artery disease (CAD). However, trial evidence for the association of intensive LDL-C lowering and TG lowering with mortality is less definitive.

Objectives

To investigate the associations of apoB, LDL-C, and TG with CAD and mortality, both overall and by sex and age, and to characterize the shapes of these associations.

Design, setting, and participants

This genetic association study used linear and nonlinear mendelian randomization (MR) to analyze a population-based cohort of individuals of European ancestry from the UK Biobank, which recruited participants from 2006 to 2010 with follow-up information updated until September 2021. Data

SUBMITTER: Yang G 

PROVIDER: S-EPMC10799266 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature