Severe Hypocalcemia With Denosumab Among Older Female Dialysis-Dependent Patients.

ABSTRACT:

Importance

Dialysis-dependent patients experience high rates of morbidity from fractures, yet little evidence is available on optimal treatment strategies. Chronic kidney disease-mineral and bone disorder is nearly universal in dialysis-dependent patients, complicating diagnosis and treatment of skeletal fragility.

Objective

To examine the incidence and comparative risk of severe hypocalcemia with denosumab compared with oral bisphosphonates among dialysis-dependent patients treated for osteoporosis.

Design, setting, and participants

Retrospective cohort study of female dialysis-dependent Medicare patients aged 65 years or older who initiated treatment with denosumab or oral bisphosphonates from 2013 to 2020. Clinical performance measures including monthly serum calci

SUBMITTER: Bird ST 

PROVIDER: S-EPMC10799290 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature