Extracellular lipidosomes containing lipid droplets and mitochondria are released during melanoma cell division.

ABSTRACT:

Background

The incidence of melanoma is increasing worldwide. Since metastatic melanoma is highly aggressive, it is important to decipher all the biological aspects of melanoma cells. In this context, we have previously shown that metastatic FEMX-I melanoma cells release small (< 150 nm) extracellular vesicles (EVs) known as exosomes and ectosomes containing the stem (and cancer stem) cell antigenic marker CD133. EVs play an important role in intercellular communication, which could have a micro-environmental impact on surrounding tissues.

Results

We report here a new type of large CD133⁺ EVs released by FEMX-I cells. Their sizes range from 2 to 6 µm and they contain lipid droplets and mitochondria. Real-time video microscopy revealed that these EVs originate from

SUBMITTER: Karbanova J 

PROVIDER: S-EPMC10799373 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature