Usual dietary intake and change in DNA methylation over years: EWAS in KORA FF4 and KORA fit.

ABSTRACT:

Introduction

Changes in DNA methylation can increase or suppress the expression of health-relevant genes. We investigated for the first time the relationship between habitual food consumption and changes in DNA methylation.

Methods

The German KORA FF4 and KORA Fit studies were used to study the change in methylation over a median follow-up of 4 years. Only subjects participating in both surveys and with available dietary and methylation data were included in the analysis (n = 465). DNA methylation was measured using the Infinium MethylationEPIC BeadChip (Illumina), resulting in 735,527 shared CpGs across both studies. Generalized estimating equation models with an interaction term of exposure and time point were used to analyze the association of 34 food groups, folic acid,

SUBMITTER: Hellbach F 

PROVIDER: S-EPMC10799384 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature