Cost-consequence analysis of continuous denosumab therapy for osteoporosis treatment in South Korea.

ABSTRACT:

Background

Insurance reimbursement provisions in South Korea limit osteoporosis medication availability for patients with T-scores exceeding - 2.5. This study aimed to evaluate the financial impact and fracture prevention of continuous denosumab therapy until a T-score>-2.0 (Dmab-C strategy), versus discontinuation of denosumab after reaching T-score>-2.5 (Dmab-D strategy) in osteoporosis patients.

Methods

A cost-consequence analysis from a Korean healthcare system perspective was performed using a newly developed Markov model. The incidence of vertebral and non-vertebral fracture, fracture-related deaths, drug costs, and fracture-treatment costs were estimated and compared between Dmab-C and Dmab-D strategy over a lifetime in eligible patients aged 55 years.

Results

SUBMITTER: Cha S 

PROVIDER: S-EPMC10799461 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature