The causality between CD8⁺NKT cells and CD16^-CD56 on NK cells with hepatocellular carcinoma: a Mendelian randomization study.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC), which is featured with high morbidity and mortality worldwide, is a primary malignant tumor of the liver. Recently, there is a wealth of supporting evidence revealing that NK cell-related immune traits are strongly associated with the development of HCC, but the causality between them has not been proven.

Methods

Two-sample Mendelian randomization (MR) study was performed to probe the causal correlation between NK cell-related immune traits and HCC. Genetic variations in NK cell-related immune traits were extracted from recent genome-wide association studies (GWAS) of individuals with European blood lineage. HCC data were derived from the UK Biobank Consortium's GWAS summary count data, including a total of 372,184 female and male s

SUBMITTER: Lu Z 

PROVIDER: S-EPMC10799464 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature