SOX9 gene shows association with adolescent idiopathic scoliosis predisposition in Northwest Indians.

ABSTRACT:

Background

Adolescent idiopathic scoliosis (AIS) is a common structural deformity of the spine affecting adolescent individuals globally. The disorder is polygenic and is accompanied by the association of various genetic loci. Genetic studies in Chinese and Japanese populations have shown the association of genetic variants of SOX9 with AIS curve severity. However, no genetic study evaluating the association of SRY-Box Transcription Factor 9 (SOX9) variants with AIS predisposition has been conducted in any Indian population. Thus, we aimed to investigate the association of the genetic variants of the SOX9 along with 0.88 Mb upstream region with AIS susceptibility in the population of Northwest India.

Methods

In total, 113 AIS cases and 500 non-AIS controls were recruited fro

SUBMITTER: Singh H 

PROVIDER: S-EPMC10799485 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature