Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance.

ABSTRACT:

Background

Uncovering the functional relevance underlying verbal declarative memory (VDM) genome-wide association study (GWAS) results may facilitate the development of interventions to reduce age-related memory decline and dementia.

Methods

We performed multi-omics and pathway enrichment analyses of paragraph (PAR-dr) and word list (WL-dr) delayed recall GWAS from 29,076 older non-demented individuals of European descent. We assessed the relationship between single-variant associations and expression quantitative trait loci (eQTLs) in 44 tissues and methylation quantitative trait loci (meQTLs) in the hippocampus. We determined the relationship between gene associations and transcript levels in 53 tissues, annotation as immune genes, and regulation by transcription factors (

SUBMITTER: Mei H 

PROVIDER: S-EPMC10799499 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature