Immunogram defines four cancer-immunity cycle phenotypes with distinct clonal selection patterns across solid tumors.

ABSTRACT:

Background

The cancer-immunity cycle (CI cycle) provides a theoretical framework to illustrate the process of the anticancer immune response. Recently, the update of the CI cycle theory emphasizes the importance of tumor's immunological phenotype. However, there is lack of immunological phenotype of pan-cancer based on CI cycle theory.

Methods

Here, we applied a visualizing method termed 'cancer immunogram' to visualize the state of CI cycle of 8460 solid tumors from TCGA cohort. Unsupervised clustering of the cancer immunogram was performed using the nonnegative matrix factorization (NMF) analysis. We applied an evolutionary genomics approach (dN/dS ratio) to evaluate the clonal selection patterns of tumors with distinct immunogram subtypes.

Results

We defined four m

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10799518 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature